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Compared to the controls, PD patients had higher contents of 3-methoxytyramine, N-acetyl-L-tyrosine, orotate, and urine vanillic acid xanthine, but lower levels of imidazolylactate 3,3-dimethylglutarate (Wang et al., 2023) (see Table 4) Table 4 Urine biomarkers in PD patients

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This means you flush out essential nutrients, like vitamin B12, through excessive urination

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